Exact® Total Sperm DNA Fragmentation Test:
The Key to Male Fertility Insights
A Deeper Look at Sperm DNA Quality and Male Fertility
Did you know that a standard semen analysis only measures sperm count, movement, and shape – but not the quality of the genetic material inside? The Exact® Total Sperm DNA Fragmentation (SDF) Test goes beyond the basics, offering a deeper look at sperm DNA integrity to help you and your clinician make informed fertility decisions.
What Does the Exact® Test Measure?

The Exact® Test measures total sperm DNA fragmentation, including both single-strand and double-strand breaks. This comprehensive analysis provides clearer insights into sperm DNA integrity, empowering you to take control of your fertility journey with confidence.
Unexplained Infertility? Sperm DNA Damage Could Be the Answer
Even when semen analysis results are normal, high DNA damage can reduce the chances of conception.
Factors That Impact Sperm DNA Fragmentation
DNA fragmentation can be affected by lifestyle (e.g. diet, alcohol, smoking), environment (e.g., exposure to excessive heat, toxins), or by certain health conditions (e.g. infection, varicocele). Knowing your total SDF damage score helps to identify whether targeted changes can be made to try to improve your sperm health.

How the Exact® Test Works: A Scientific Breakthrough
The ISO-accredited Exact® SDF test is based on our SpermComet® assay, which applies a highly sensitive technique called single-cell gel electrophoresis. This method gently unwinds the tightly packed DNA within each sperm cell so that any DNA fragmentation present can be directly measured.
Other tests only estimate susceptibility to DNA damage, but Exact® provides a direct measurement of the DNA damage itself with exceptional accuracy and clinical usefulness for Total SDF damage.
Schedule Your Exact® Test Today
Fast, reliable, and ISO-accredited testing.