Exact® – Total Sperm DNA
Fragmentation Test

What is the Exact Test Used For?

The Exact test is used in male fertility assessments to help understand sperm health beyond standard semen analysis. It is particularly useful for:

• Diagnosing unexplained male infertility – Even men with a normal semen analysis can have high levels of DNA damage that may affect fertility
• Guiding fertility treatment decisions – Assessing sperm DNA integrity can help fertility specialists choose the most suitable approach for assisted reproductive treatments (ART).
• Investigating recurrent miscarriage – Research has shown that sperm DNA fragmentation can be a contributing factor in unexplained pregnancy loss.
• Assessing lifestyle and medical impacts on sperm health – Total SDF damage can be influenced by lifestyle, environmental factors, and certain medical conditions. Identifying SDF levels allows for potential lifestyle adjustments or clinical interventions.

How the Exact Test Can Benefit Patients

For individuals and couples trying to conceive, the Exact test provides:

• A deeper understanding of sperm health – Offers insights beyond a standard semen analysis, helping to uncover hidden fertility challenges.
• More informed fertility planning – Helps patients and clinicians make evidence-based decisions about the next steps in fertility care.
• Opportunities for improvement – If sperm DNA fragmentation is identified, targeted lifestyle changes, medical treatments, or adjustments in ART approaches may be recommended.
• A proactive approach to male fertility – Rather than enduring multiple failed ART cycles, the Exact test helps men take an active role in understanding and improving their fertility from the start.

How the Exact Test Helps Clinicians

For fertility specialists and healthcare professionals, the Exact test provides:

• A diagnostic advantage – Identifies sperm DNA fragmentation levels, which are not detected through standard semen analysis, allowing for a more complete male fertility assessment.
• Enhanced treatment decisions – Provides key diagnostic information to help tailor fertility treatments based on sperm DNA quality.
• Optimised patient journeys – Empowers clinicians to offer evidence-based recommendations on lifestyle changes, treatment options, and fertility care strategies.